TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma
Our findings of this study demonstrate that TMP exerts a dual-action mechanism by modulating both apoptosis and autophagy, thus offering a promising strategy to overcome drug resistance in HCC.
Authors
- Acharan S. Narula
- Sulaiman Ali Alharbi (ORCID: https://orcid.org/0000-0002-4196-2746)
- Yejin Hong
- Gautam Sethi (ORCID: https://orcid.org/0000-0002-8677-8475)
- Kwang Seok Ahn
- Arunachalam Chinnathambi (ORCID: https://orcid.org/0000-0001-5075-5901)
- Dongwoo Nam (ORCID: https://orcid.org/0000-0002-7957-3121)
- Kam M. Hui (ORCID: https://orcid.org/0000-0003-1820-1399)
- Amudha Deivasigamani
- Ojas A. Namjoshi (ORCID: https://orcid.org/0000-0002-2142-3702)
- Bruce E. Blough (ORCID: https://orcid.org/0000-0003-3515-0896)
- Young Yun Jung (ORCID: https://orcid.org/0000-0002-9101-9641)
Institutions
- National University of Singapore (SG)
- RTI International (US)
- King Saud University (SA)
- Kyung Hee University (KR)
- BD Biosciences (United States) (US)
- National Cancer Centre Singapore (SG)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.lfs.2024.123316
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Research Foundation of Korea