Long-term outcomes of ganglionated plexus ablation as sole therapy for paroxysmal atrial fibrillation
The autonomic nervous system, through the ganglionated plexus (GP), is known to contribute to the arrhythmogenesis of atrial fibrillation (AF). The GANGLIA-AF trial was a prospective, multicenter, randomized, single-blinded study (NCT02487654) randomizing paroxysmal AF patients to either stand-alone left atrial ectopy-triggering GP (ET-GP) ablation or standard pulmonary vein isolation (PVI) only.1 The trial was unique in that it performed detailed mapping of the left atrium, surveying for sites that triggered atrial ectopy or AF by high-frequency, high-output stimulation within the local atrial refractory period.
Authors
- Jamie Kay
- Prapa Kanagaratnam (ORCID: https://orcid.org/0000-0003-3593-2185)
- Michael Koa‐Wing
- Nick Linton (ORCID: https://orcid.org/0000-0002-5712-849X)
- Clare Coyle (ORCID: https://orcid.org/0000-0001-9271-2491)
- Ian J. Wright (ORCID: https://orcid.org/0000-0001-8338-9143)
- Michael Fudge (ORCID: https://orcid.org/0000-0002-9994-3708)
- Elaine Hsuen Lim (ORCID: https://orcid.org/0000-0002-4660-3187)
- Norman Qureshi (ORCID: https://orcid.org/0000-0002-1385-5484)
- David R. Tomlinson (ORCID: https://orcid.org/0000-0002-4417-5502)
- Gurpreet Dhillon (ORCID: https://orcid.org/0000-0002-1197-9328)
- Zachary I. Whinnett (ORCID: https://orcid.org/0000-0002-2775-5126)
- Fu Siong Ng (ORCID: https://orcid.org/0000-0002-8681-4368)
- Louisa Malcolme‐Lawes
- Phang Boon Lim (ORCID: https://orcid.org/0000-0003-4888-0070)
- Nicholas S. Peters (ORCID: https://orcid.org/0000-0002-3581-8078)
- Min-Young Kim (ORCID: https://orcid.org/0000-0003-4415-6464)
- Ross J. Hunter (ORCID: https://orcid.org/0000-0002-4641-3279)
Institutions
- St Bartholomew's Hospital (GB)
- Imperial College Healthcare NHS Trust (GB)
- Barts Health NHS Trust (GB)
- Hammersmith Hospital (GB)
- Derriford Hospital (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- University Hospitals Plymouth NHS Trust (GB)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.hrthm.2024.12.010
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- NIHR Imperial Biomedical Research Centre