Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial
The 10-week multimodal exercise intervention mainly affected circulating T cells harboring a pathophysiological phenotype in MS. The findings of a decreased frequency of pathogenic Th17 cells and the reduced CNS-homing potential of CD8<sup>+</sup> T cells, indicated by reduced CD49d MFI, substantiate the positive effects of exercise on cellular biomarkers involved in disease activity and progression in MS. To confirm exercise-mediated beneficial effects on both disease domains, clinical endpoints (i.e., relapse rate, lesion formation, EDSS score) should be assessed together with these cellular and molecular markers in studies with a larger sample size and a duration of six to twelve months or longer.
Authors
- Wilhelm Bloch (ORCID: https://orcid.org/0000-0003-1786-8853)
- Sergen Belen (ORCID: https://orcid.org/0000-0001-9074-3198)
- Philipp Zimmer (ORCID: https://orcid.org/0000-0001-9631-4503)
- Annette Rademacher (ORCID: https://orcid.org/0000-0002-6743-3551)
- Sebastian Proschinger (ORCID: https://orcid.org/0000-0001-8173-1515)
- Alexander Schenk (ORCID: https://orcid.org/0000-0002-3122-714X)
- Clemens Warnke (ORCID: https://orcid.org/0000-0002-3510-9255)
- Marit Lea Schlagheck (ORCID: https://orcid.org/0000-0002-8913-6080)
- Frederike Adammek (ORCID: https://orcid.org/0009-0005-2519-4360)
Institutions
- German Sport University Cologne (DE)
- University of Cologne (DE)
- TU Dortmund University (DE)
- Institute for Sports Medicine (DE)
- University Hospital Cologne (DE)
- Asklepios (DE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.bbi.2024.12.017
- Citations
- 6
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Hans Böckler Stiftung
- Marga und Walter Boll-Stiftung