Interferon signaling is enhanced by ATR inhibition in glioblastoma cells irradiated with X-rays, protons or carbon ions
These findings indicate that DNA damage response inhibitors can enhance IFN signaling following X-, proton and carbon ion irradiation, with a strong positive dependency on LET.
Authors
- Randi G. Syljuåsen (ORCID: https://orcid.org/0000-0003-3404-6069)
- Adrian Eek Mariampillai
- Diana Savu (ORCID: https://orcid.org/0000-0002-0145-5176)
- Nina Frederike Jeppesen Edin (ORCID: https://orcid.org/0000-0002-6995-131X)
- Gro Elise Rødland
- François Chevalier (ORCID: https://orcid.org/0000-0002-8488-2324)
- Mihaela Temelie (ORCID: https://orcid.org/0000-0003-0436-754X)
- Eirik Malinen (ORCID: https://orcid.org/0000-0002-1308-9871)
- Antoine Gilbert
- Ana Maria Serban
- Lilian Lindbergsengen
Institutions
- Oslo University Hospital (NO)
- Centre National de la Recherche Scientifique (FR)
- University of Oslo (NO)
- École Nationale Supérieure d'Ingénieurs de Caen (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering (RO)
- Centre de Recherche sur les Ions, les Matériaux et la Photonique (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.radonc.2024.110669
- Citations
- 7
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Kreftforeningen
- EEA Grants/Norway Grants