Chinese Yam-Derived Adhesive Microgel for Effective Management of Uncontrolled Hemorrhage and Trauma-Induced Skin Wounds

Chinese yam (<i>Dioscorea opposita</i>), a traditional medicinal plant, has gained renewed interest in contemporary research due to its broad therapeutic potential. In this study, we developed an adhesive yam microgel through a series of peeling, grinding, sieving, and rehydration processes. Our in vitro experiments demonstrated that the yam microgel was noncytotoxic, effectively scavenged free radicals, and promoted cell migration. Additionally, the microgels exhibit good blood compatibility and biodegradability. In vivo, we first evaluated the hemostatic properties of the yam microgel in different hemorrhage models in rats. It demonstrated strong hemostatic capabilities because it could adsorb many blood cells and platelets, activate platelets, and facilitate coagulation. Furthermore, we observed that the yam microgel promotes the repair of acute skin tissue defects by enhancing cell proliferation and neovascularization as well as modulating the inflammatory response, thereby accelerating wound healing. Finally, we found that the yam microgel can serve as a biological adhesive, effectively promoting wound closure through a mechanism similar to its role in facilitating skin tissue repair. The design of a low-cost, safe, and effective yam microgel will provide a promising strategy for hemostasis and wound healing.