Blood Plasma Metabolomic and Lipidomic Signatures of Prostate Cancer Using NMR Spectroscopy

Prostate cancer (PCa) with metastasis remains an incurable disease requiring early diagnosis and effective treatments. Bone metastasis is the predominant cause of mortality from PCa. Aggressive PCa metastasizes or spreads to bones, such as the hip, spine, and pelvis. Bone metastatic PCa is considered an advanced stage. This study was designed to determine the association of these metabolites/lipids with the progression of metastases cascade in PCa. Thus, the present study is based on 1H-NMR to investigate the blood plasma metabolomic and lipidomic profile to distinguish PCa patients with metastases from those without metastases for determining potential biomarker/s for progression to metastases cascade.