Colon mucosal proteomics of ankylosing spondylitis versus gut inflammation
NMRAL1 is identified as a key differentially expressed protein in AS patients with gut inflammation. Knockdown of NMRAL1 significantly reduced the levels of inflammatory cytokines, suggesting its potential role in the pathogenesis of AS and gut inflammation, and as a possible therapeutic target.
Authors
- Siqi Xiao
- Yingxin Liu (ORCID: https://orcid.org/0000-0003-3979-0479)
- Xiaojin He (ORCID: https://orcid.org/0000-0002-2262-416X)
- Hua Chen (ORCID: https://orcid.org/0000-0002-5582-0140)
- Lei Wang (ORCID: https://orcid.org/0009-0005-0050-0691)
- Jianmei Chen (ORCID: https://orcid.org/0000-0001-9707-3879)
- Miao Cheng (ORCID: https://orcid.org/0000-0002-6510-9520)
- Y. Guan
- Shaer Kayi
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1371/journal.pone.0315324
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Jiangsu Science and Technology Department