FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway
This study highlights FBLN1 as a critical regulator of ferroptosis in ARDS. Targeting the TGF-β/Smad pathway to modulate FBLN1 expression offers a potential therapeutic strategy to alleviate oxidative stress and mitigate pulmonary injury in inflammatory lung diseases.
Authors
- Yang Zhao (ORCID: https://orcid.org/0000-0001-8814-7004)
- Yu-Feng Yan (ORCID: https://orcid.org/0000-0002-8468-4002)
- Wenchao Gu (ORCID: https://orcid.org/0000-0002-1505-9887)
- Qinyun Ma (ORCID: https://orcid.org/0000-0002-0867-2114)
- Edward Kim (ORCID: https://orcid.org/0000-0002-8660-7465)
- Jin Bai
- Haihan Song (ORCID: https://orcid.org/0009-0006-7753-8628)
- Yaping Yuan (ORCID: https://orcid.org/0009-0004-8737-1396)
- Youbo Wang
Institutions
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Huashan Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1371/journal.pone.0314750
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Shanghai Municipal Health Commission
- Fudan University