THE RESPONSE OF BULLS ORGANISM TO NON-SPECIFIC STIMULATORS OF RESISTANCE AND THE FORMATION OF IMMUNE-BIOLOGICAL REACTIVITY

The intense man-made load on agro-ecosystems causes a negative impact on the physiological, clinical, productive state of animals and has a negative effect as a stress factor on the body's immune system. The conducted studies confirm that man-made loads on the animal body, as well as the use of non-specific stimulants of resistance, exacerbate the problem of regulating disorders of the immune system. The factors causing a decrease in the immune status, as well as the resistance of the animal body, include: industrial technology of animal breeding, chemicalization in crop production, man-made pressure, imbalance of the diet in terms of nutrients and biologically active substances. The very mechanism of the development of the body's reaction to non-specific factors of resistance formation, i.e. immuno-biological reactivity, is closely related to the activity of POL (lipid peroxidation) and the depression of the antioxidant potential. Under these conditions, the ability of the body to mobilize protective and adaptive capabilities in response to the action of both negative factors in general and nonspecific stimulators of resistance acquires special importance (Chumachenko & Pavlenko, 2004; Velychko, 2008, 2011). Under the conditions of the impact of man-made load and non-specific stimulators of resistance on the animal body, effective and already confirmed practice is the use of effective, proven methods of regulating the activity of the enzymatic system of antioxidant protection with the use of biologically active substances, in particular trace elements and vitamins. The results of the conducted research confirm that this has a positive effect on the formation of the immunobiological reactivity of the animal body and significantly reduces the influence of non-specific stimulants of resistance. And this is an opportunity to directly (aggressively) influence the formation of productive and adaptive properties of animals, which is important for the quality and safety of products of animal origin. Therefore, knowledge of the laws of the formation of the body's resistance, correspondingly its immune-biological reactivity, is important in the development of methods for the correction of the immunodeficiency state, antioxidant protection.