ACUTE AND SUBACUTE TOXICITY OF THE PREPARATION BASED ON THE ANTIBIOTIC PAROMOMYCIN

Antibiotics are currently the most common drugs widely used in veterinary medicine. The article presents the results of a study of the acute and subacute toxicity of a drug based on the antibiotic paromomycin. The acute toxicity parameters of the drug “Gabbrovet Multi” were studied in white rats, 2-3 months old, weighing 180-200 g. The drug was administered intragastrically, once. To determine the toxicity of the drug “Gabbrovet Multi” for white rats, doses of 1000, 3000 and 5000 mg/kg of animal body weight were taken. 6 laboratory animals were used for each dose. Subacute toxicity was studied on 18 white rats weighing 180-200 g. For this purpose, a control and two experimental groups of animals were formed on the principle of analogues, 6 rats each. The animals of the control group were administered water. The animals of the first experimental group were administered “Gabbrovet Multi” in a therapeutic dose of 0.05 ml per animal, the animals of the second experimental group were administered tenfold the therapeutic dose of 0.5 ml per animal. In the subacute experiment, “Gabbrovet Multi” was administered to rats for 10 days. As a result of acute toxicity studies, it was found that after administration of Gabbrovet Multi to white rats in various doses, all animals remained alive, actively consumed water and food. During the subacute toxicity study, no deaths of laboratory rats were observed. On the 11th day of the experiment, when the drug was administered in experimental doses, no significant changes in the mass coefficients of the liver, kidneys, heart, spleen and lungs were found compared to the control, and no significant changes in hematological blood parameters were found or noted. When studying the effect of the drug on the biochemical parameters of blood serum in animals of the experimental groups, an increase in the activity of ACE was found, indicating toxic liver damage. Under conditions of intragastric administration of the drug “Gabbrovet Multi” LD50 for white rats is more than 5000 mg/kg body weight. The drug belongs to low-toxic substances. The use of the drug “Gabbrovet Multi” in therapeutic and ten-fold therapeutic doses for 10 days leads to liver damage in animals of the experimental groups.