Novel risk predictor of arrhythmias for patients with potassium channel–related congenital long QT syndrome
Our findings suggest that in patients with LQTS, dynamic QT interval measures obtained during the EST are associated with lifetime arrhythmic events and events after the EST. Such measures can be helpful in identifying a higher-risk subset of patients with LQTS in order to optimize their management. Further research may confirm these findings in larger cohorts and explore the potential benefit of combining genetic and EST data for more precise risk stratification.
Authors
- Arthur A.M. Wilde (ORCID: https://orcid.org/0000-0002-0528-0852)
- Christian Krijger Juárez (ORCID: https://orcid.org/0000-0003-1603-7484)
- Sven Dittmann (ORCID: https://orcid.org/0000-0001-5829-3676)
- Peter J. Schwartz (ORCID: https://orcid.org/0000-0003-0367-1048)
- Michael W.T. Tanck (ORCID: https://orcid.org/0000-0001-9828-4459)
- Connie R. Bezzina (ORCID: https://orcid.org/0000-0002-0633-3514)
- Jasmin Mujkanovic (ORCID: https://orcid.org/0000-0001-9682-7325)
- John R. Giudicessi (ORCID: https://orcid.org/0000-0001-5871-0265)
- Lia Crotti (ORCID: https://orcid.org/0000-0001-8739-6527)
- V M Proost
- Julien Barc (ORCID: https://orcid.org/0000-0003-4106-5946)
- Aurélie Thollet
- Raquel Neves (ORCID: https://orcid.org/0000-0003-2619-0036)
- Michael John Ackerman (ORCID: https://orcid.org/0000-0002-8011-3333)
- J. Martijn Bos (ORCID: https://orcid.org/0000-0002-3635-2003)
- Maarten P. van den Berg (ORCID: https://orcid.org/0000-0002-1493-2998)
- Eric Schulze‐Bahr (ORCID: https://orcid.org/0000-0001-6884-2501)
- Fulvio L F Giovenzana (ORCID: https://orcid.org/0009-0006-3902-153X)
- Federica Dagradi (ORCID: https://orcid.org/0000-0002-1090-3292)
- Aurélien Clédel
- Giulia Musu (ORCID: https://orcid.org/0000-0002-5596-1349)
- Jacob Tfelt‐Hansen (ORCID: https://orcid.org/0000-0003-3895-9316)
- Vincent Probst
- Corinna Rickert
Institutions
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Mayo Clinic (US)
- University Medical Center Groningen (NL)
- Inserm (FR)
- University of Groningen (NL)
- Copenhagen University Hospital (DK)
- University Hospital Münster (DE)
- Amsterdam Neuroscience (NL)
- IRCCS Istituto Auxologico Italiano (IT)
- ERN GUARD-Heart (NL)
- Institut du Thorax (FR)
- Amsterdam University Medical Centers (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Amsterdam (NL)
- Nantes Université (FR)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.hrthm.2024.12.015
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- ZonMw