Insight into the Key Factors that Influence the Reaction Pathways in the Silyl‐Prins Cyclization of <i>gem</i>‐Vinylsilyl Alcohols
Abstract This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of gem ‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these distinct pathways. The process enables the chemo‐ and stereocontrolled formation of a variety of structural frameworks, offering significant potential for the generation of a broad range of molecular architectures.
Authors
- Israel Fernández (ORCID: https://orcid.org/0000-0002-0186-9774)
- Laura Fernández-Peña (ORCID: https://orcid.org/0000-0002-4444-0062)
- Carlos Díez‐Poza (ORCID: https://orcid.org/0000-0002-9613-0680)
- Asunción Barbero (ORCID: https://orcid.org/0000-0001-6825-7775)
- Paula González-Andrés (ORCID: https://orcid.org/0000-0003-0349-984X)
- Daniel Gónzalez-Pinardo (ORCID: https://orcid.org/0009-0002-1151-2872)
Institutions
- Universidad de Valladolid (ES)
- Universidad Complutense de Madrid (ES)
- Instituto de Química Orgánica General (ES)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1002/adsc.202401437
- Citations
- 2
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Comunidad de Madrid
- Universidad de Valladolid
- Junta de Castilla y León
- Agencia Estatal de Investigación