Correlation between lipid profile and cognitive function deterioration in ischemic stroke patients

Context: The second most common type of dementia is vascular dementia, caused by cerebrovascular disease. The decline in cognitive function after ischemic stroke occurs with varying degrees of severity and onset. This variability is attributed to the overlapping neurodegenerative and vascular damage. Aims: To investigate the correlation between lipid profile, a biomarker of vascular dysfunction, and cognitive function in ischemic stroke patients. Methods: A total of 52 respondents (mean age 64.21 ± 9.78 years) were recruited, and the Spearman correlation test found a moderate positive correlation (r=0.658, p=0.04) between lipid profile and cognitive function deterioration. The ordinal regression analysis was used to calculate the odds ratio (OR). Results: The results showed that the OR for cognitive function deterioration associated with high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, and total cholesterol were -1.54 (95% CI -0.98 - -3.46, p=0.002), 1.78 (95% CI 1.27-2.46, p=0.000), 2.48 (95% CI 1.39-4.92, p=0.04), and 1.54 (95% CI 1.04-2.48, p=0.003) respectively. Conclusion: Based on the results, a positive correlation with moderate strength was observed between lipid profile and cognitive function deterioration in ischemic stroke patients.