Selecting High-Risk Patients With Pediatric Crohn’s Disease for Top-Down Anti-TNF as per the 2021 ECCO-ESPGHAN Guidelines: A 5-Year Nationwide Retrospective Analysis From Scotland (2016-2020)
Our data support the guideline's ability to identify patients more likely to require early treatment escalation. However, this approach would have led to potential over- and under-treatment in a substantial proportion of patients. This underscores the importance of frequent and comprehensive monitoring, along with flexible treatment strategies that adapt to changes in disease status.
Authors
- David C. Wilson (ORCID: https://orcid.org/0000-0001-9454-951X)
- Gregor Scott
- Richard Hansen (ORCID: https://orcid.org/0000-0002-3944-6646)
- Iain Chalmers (ORCID: https://orcid.org/0009-0004-1995-3167)
- D Wands (ORCID: https://orcid.org/0000-0002-2500-6041)
Institutions
- University of Dundee (GB)
- Royal Hospital for Children (GB)
- Royal Aberdeen Children's Hospital (GB)
- Royal Hospital for Sick Children (GB)
- Centre for Inflammation Research (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1093/ibd/izae298
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.55