Drug Delivery Methods for Compromised Skin

Background Topical and transdermal delivery methods are explored to understand efficient techniques to deliver drugs to damaged skin. The objective of this paper is to review recent studies to interpret drug delivery efficiency when skin has been compromised with disease or treatment. Methods Using search engines and inclusive word choices to search and compile recent research on the subject matter of topical drug delivery. After removing articles not benefiting the review, 11 studies were included. Results Betamethasone dipropionate spray a topical corticoid cream, improves skin conditions like psoriasis. The Er:YAG laser increased vitamin c levels 86% and microdermabrasion moderately increased vitamin c levels by 20 fold compared to untreated skin. An increased TEWL and a decrease in permeation depth determines effectiveness of GMO-based cubic liquid crystals (Ma et al., 2020). Various microneedles were an effective method to deliver insulin and decrease blood glucose. Conclusion Relativity few transdermal drugs are commercialized partially because of the challenge to penetrate stratum corneum; microneedling may offer potential for such purposes. Betamethasone dipropionate spray and GMO-based cubic liquid crystals are novel and may be potentially effective for treating psoriasis and laser damage respectively.