Natural small molecule hinokitone mitigates NASH fibrosis by targeting regulation of FXR-mediated hepatocyte apoptosis
In conclusion, HO has an inhibitory effect on NASH fibrosis. This effect is mediated by targeting upregulation of hepatocyte FXR, which in turn attenuates hepatocyte apoptosis and thus indirectly inhibits the activation of HSCs.
Authors
- Ankang Peng (ORCID: https://orcid.org/0000-0001-9200-1075)
- Rong Qi (ORCID: https://orcid.org/0000-0002-0627-9968)
- Ying‐Kun Qiu (ORCID: https://orcid.org/0000-0003-0181-2927)
- Yitong Hu (ORCID: https://orcid.org/0009-0008-1697-1465)
- Tiantian Song (ORCID: https://orcid.org/0000-0002-8048-4038)
- Zhe-Wei Yu
- Ze-Jiang Ma
Institutions
- Xiamen University (CN)
- Peking University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.jare.2024.12.016
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Kunming University of Science and Technology
- Peking University
- Tianjin Medical University
- Beijing Municipal Natural Science Foundation