Human plasma inositol hexakisphosphate (InsP6) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1)
Inositol hexakisphosphate (InsP <sub>6</sub> ), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP <sub>6</sub> molecules are associated with magnesium. Calcium is the prevalent bivalent cation outside the cell and its association with InsP <sub>6</sub> could lead to the formation of insoluble complexes. To avoid the formation of dangerous InsP <sub>6</sub> /Calcium precipitates in the bloodstream, mammals must possess a robust InsP <sub>6</sub> phosphatase in their plasma. Here we identify the Multiple Inositol Polyphosphate Phosphatase 1 ( MINPP1 ) as the InsP <sub>6</sub> phosphatase present in human plasma.
Authors
- Valeria Fedeli (ORCID: https://orcid.org/0000-0002-6392-9963)
- Adolfo Saiardi (ORCID: https://orcid.org/0000-0002-4351-0081)
- Vincent Cantagrel (ORCID: https://orcid.org/0000-0002-5180-4848)
- Jingyi Wang (ORCID: https://orcid.org/0000-0003-0465-6253)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- MRC Laboratory for Molecular Cell Biology (GB)
- University College London (GB)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-16
- DOI
- https://doi.org/10.17912/micropub.biology.001390
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Medical Research Council