Integrative multi‐omics reveals the mechanism of ulcerative colitis treated with Ma‐Mu‐Ran antidiarrheal capsules
Based on a thorough multi-omics analysis of transcriptomics, metabolomics, and gut flora, it was determined that MMRAC regulated cysteine and methionine metabolism, arginine biosynthesis, and sphingolipid metabolism and their respective genes BHMT, PHGDH, iNOS, and SPHK1, which in turn served to inhibit UC-generated inflammatory responses and oxidative stress. Additionally, MMRAC regulated the abundance of Coprococcus, Helicobacter, Sutterella, Paraprevotella, and Roseburia in the intestinal tracts of UC mice, which was regulated toward normal levels, thereby restoring normal intestinal function.
Authors
- Lintao Han (ORCID: https://orcid.org/0000-0002-7858-6756)
- Si‐Li Zheng (ORCID: https://orcid.org/0000-0001-8682-9343)
- Bailu Duan (ORCID: https://orcid.org/0000-0002-1632-665X)
- Jiajing Liu (ORCID: https://orcid.org/0000-0003-3268-6070)
- Yuxin Wen (ORCID: https://orcid.org/0000-0002-2352-5622)
- Peng-Yu Chen (ORCID: https://orcid.org/0000-0002-5577-5546)
- Jingjing Li (ORCID: https://orcid.org/0000-0001-9638-7964)
- Shanshan Wang (ORCID: https://orcid.org/0000-0002-1102-0483)
- Qiong Wang (ORCID: https://orcid.org/0000-0003-0334-7395)
- Ye Yan (ORCID: https://orcid.org/0000-0002-7514-0505)
- Fang Huang (ORCID: https://orcid.org/0000-0003-3876-1123)
- Ping Huang (ORCID: https://orcid.org/0000-0001-8726-8816)
- Hailing Huang (ORCID: https://orcid.org/0000-0003-2311-0897)
- Zhuang Huang (ORCID: https://orcid.org/0000-0003-4666-3267)
- Dongning Zhang (ORCID: https://orcid.org/0000-0002-5511-4051)
- Qi Jiang (ORCID: https://orcid.org/0009-0007-9498-5873)
Institutions
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1002/rcm.9939
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00