Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes
Our study demonstrated that Brg1 and RUNX1 formed a transcriptional complex that modulated TRPM4 expression and function, especially under hypoxic conditions. These findings provided new insights into TRPM4 regulation and highlighted its potential as a therapeutic target for cardiac hypoxia-related disorders.
Authors
- Tingting Tong
- Ziyue Ma (ORCID: https://orcid.org/0000-0001-5787-5738)
- Mei‐Mei Shen
- Yadong Xue (ORCID: https://orcid.org/0000-0002-0363-9702)
- Ling Zhao (ORCID: https://orcid.org/0000-0002-6644-2886)
- Yongzhen Wang (ORCID: https://orcid.org/0000-0002-0440-1181)
- Kai Zhang (ORCID: https://orcid.org/0000-0003-2800-0531)
- Jing Li (ORCID: https://orcid.org/0000-0003-3209-8973)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Jing Jin (ORCID: https://orcid.org/0000-0002-5592-4206)
- Yuyang Fu
- Lingzhao Xiong
- Rong Huo
- Xian-Hui Dong
- Yu Zhao (ORCID: https://orcid.org/0000-0003-3295-7379)
- Tao Ban (ORCID: https://orcid.org/0000-0001-6505-6193)
- Yuxuan Han (ORCID: https://orcid.org/0000-0002-2844-5074)
- Yunfeng Cui (ORCID: https://orcid.org/0000-0001-9665-0515)
- Hongzhao Lv
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
- Heilongjiang Academy of Sciences (CN)
- Ministry of Science ICT and Future Planning (KR)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fphar.2024.1494205
- Citations
- 1
- Primary Topic
- Magnesium Alloys: Properties and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.17
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Heilongjiang Provincial Postdoctoral Science Foundation