Mild autonomous cortisol secretion leads to reduced volumetric BMD at lumbar spine in patients with primary aldosteronism
Despite non-significant differences in bone turnover markers between patients with PA with or without MACS, CT scans revealed significantly reduced vBMD in PA and MACS patients, indicating compromised bone health and vBMD significantly negatively correlated with cortisol post DST. Thus, opportunistic evaluation of vBMD in routine CT screenings could aid in the early detection of bone alterations in MACS and help mitigate potential long-term adverse effects on bone health.
Authors
- Stephanie Zopp
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- V. F. Vasil'eva
- Ulrich Dischinger (ORCID: https://orcid.org/0009-0008-4885-9355)
- Denise Brüdgam (ORCID: https://orcid.org/0009-0009-2296-0962)
- Osman Öcal (ORCID: https://orcid.org/0000-0001-5234-1921)
- Friederike Völter (ORCID: https://orcid.org/0000-0001-6157-0363)
- Nicole Reisch (ORCID: https://orcid.org/0000-0002-7469-6069)
- Isabel Stüfchen (ORCID: https://orcid.org/0009-0007-6846-6893)
- Martin Bidlingmaier (ORCID: https://orcid.org/0000-0002-4681-6668)
- Nabeel Mansour (ORCID: https://orcid.org/0000-0002-3467-1916)
- Jens Ricke (ORCID: https://orcid.org/0000-0001-8762-8594)
- Moritz Wildgruber (ORCID: https://orcid.org/0000-0002-7228-6963)
- Max Seidensticker (ORCID: https://orcid.org/0000-0002-2481-5410)
- Daniel Heinrich (ORCID: https://orcid.org/0000-0002-7086-0562)
- J. Schweizer
- Elisabeth Nowak (ORCID: https://orcid.org/0000-0002-7323-9085)
Institutions
- University of Würzburg (DE)
- LMU Klinikum (DE)
- Universitätsklinikum Würzburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fendo.2024.1521680
- Citations
- 2
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung