SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant
Our results uncover an endogenous neuroprotective mechanism, whereby SUMO2 conjugation reduces Tau neuropathology and protects against toxic effects of Tau in glial cells.
Authors
- Rosaria Pascente (ORCID: https://orcid.org/0000-0002-2264-7898)
- Paul E. Fraser (ORCID: https://orcid.org/0000-0003-1227-4239)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- Luana Fioriti (ORCID: https://orcid.org/0000-0003-2429-8967)
- Franca Orsini (ORCID: https://orcid.org/0000-0001-7415-9936)
- Annacarla Martucci
- Sara Palacino
Institutions
- University of Toronto (CA)
- Mario Negri Institute for Pharmacological Research (IT)
- Occupational Cancer Research Centre (CA)
- Columbia University (US)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fncel.2024.1437995
- Citations
- 3
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Alzheimer's Association
- Fondazione Telethon
- National Institutes of Health
- Canadian Institutes of Health Research