Attenuation of neutrophil adhesion and formation of neutrophil extracellular traps by pooled human immune globulins
These findings show the dose-dependent efficacy of pooled human immune globulins, specifically Flebogamma<sup>®</sup> DIF against experimentally and pathologically induced NETosis and neutrophil adhesion to corneal epithelial cells, <i>in vitro</i>. The results from this study support the continued clinical development of Flebogamma<sup>®</sup> 5% DIF as a novel and efficacious treatment for the signs and symptoms of dry eye disease.
Authors
- Simon Kaja (ORCID: https://orcid.org/0000-0001-6878-521X)
- S.I. Iqbal (ORCID: https://orcid.org/0009-0005-6191-0539)
- Vidhya R. Rao (ORCID: https://orcid.org/0000-0002-1465-2646)
- Christine Mun
- Sandeep Jain (ORCID: https://orcid.org/0000-0002-5815-370X)
- Bradford A. Young
Institutions
- Loyola University Chicago (US)
- Edward Hines, Jr. VA Hospital (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fphar.2024.1465776
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Research to Prevent Blindness
- National Eye Institute