Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation

Tomatidine can alleviate neuronal damage in SCI by inhibiting apoptosis and inflammation through the NF-κB/CXCL10 pathway. Our findings provide a novel therapeutic target and candidate for the treatment of SCI.

Authors

Wei Huang (ORCID: https://orcid.org/0000-0002-6943-5892)
Hua Wang
Dongxu Wang (ORCID: https://orcid.org/0000-0001-7377-6190)
Yongxiang Wang (ORCID: https://orcid.org/0000-0002-2003-6006)
Hao Sun (ORCID: https://orcid.org/0000-0002-9456-5824)
Xu Wang (ORCID: https://orcid.org/0009-0006-6379-9077)

Institutions

Jiangsu University of Science and Technology (CN)
Northern Jiangsu People's Hospital (CN)
Yangzhou University (CN)
Nanjing Medical University (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2024-12-12
DOI: https://doi.org/10.3389/fphar.2024.1503925
Citations: 5
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 1.24

Funders

National Natural Science Foundation of China
Government of Jiangsu Province

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article

Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation

Wei Huang, Hua Wang, Dongxu Wang, Yongxiang Wang et al.

Dec 12, 2024

5 citations

Frontiers in Pharmacology

Neuroinflammation and Neurodegeneration Mechanisms

1.24

article

Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation

Wei Huang, Hua Wang, Dongxu Wang, Yongxiang Wang, Hao Sun, Xu Wang

December 12, 2024article en

5 citations

Abstract

Tomatidine can alleviate neuronal damage in SCI by inhibiting apoptosis and inflammation through the NF-κB/CXCL10 pathway. Our findings provide a novel therapeutic target and candidate for the treatment of SCI.

Frontiers in PharmacologyVol. 15

Jiangsu University of Science and Technology (CN), Northern Jiangsu People's Hospital (CN), Yangzhou University (CN), Nanjing Medical University (CN)

National Natural Science Foundation of China, Government of Jiangsu Province

Good health and well-being

Openalex Percentile: Top 19%

Neuroinflammation and Neurodegeneration Mechanisms

1.24

DOI Open Access PDF OpenAlex

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Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation — Wei Huang, Hua Wang, et al. · Frontiers in Pharmacology (2024) | TGRS Research Map | TGRS