Computational exploration of palmitoyl-protein thioesterase 1 inhibition by Juniperus phoenicea L. for anti-dementia treatment
This <i>in silico</i> study was aimed at identifying potential inhibitors of PPT1 from <i>J. phoenicea</i> phytochemicals, given that PPT1 is a target for developing new dementia medications. Our findings identified amentoflavone as a promising candidate for further investigation. These findings warrant further research to validate this compound's potential as a PPT1 inhibitor for dementia treatment.
Authors
- Riyan Alifbi Putera Irsal (ORCID: https://orcid.org/0000-0001-6271-5632)
- Gusnia Meilin Gholam (ORCID: https://orcid.org/0000-0001-7142-5856)
- Fernanda Chairunisa (ORCID: https://orcid.org/0009-0000-5043-012X)
- Maheswari Alfira Dwicesaria
- Tiyara F Mansyah
Institutions
- IPB University (ID)
- Universitas Ibn Khaldun Bogor (ID)
- Bioinformatics Institute (RU)
- Bioinformatics Institute (SG)
- Nasional University (ID)
Publication Details
- Journal
- Journal of Taibah University Medical Sciences
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.jtumed.2024.12.005
- Citations
- 2
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.72