Sc(OTf)<sub>3</sub>‐Catalyzed Tunable Thio‐(3+3) Annulation Reactions of Indoline‐2‐thiones with α‐Benzylidene‐β‐tetralones
Abstract A Sc(OTf) 3 ‐catalyzed tunable thio‐Michael addition/nucleophilic addition/dehydration reaction of indoline‐2‐thiones with α‐benzylidene‐β‐tetralones was realized, leading to biologically important tetrahydrobenzo[7,8]isothiochromeno[3,4‐b]indoles and thiazino[3,2‐a]indoles in moderate to good yields. Moreover, by extending the reaction time, the dehydrogenated cycloadducts dihydrobenzo[7,8]isothiochromeno[3,4‐b]indoles were also obtained from the reaction of indoline‐2‐thiones with α‐benzylidene‐β‐tetralones.
Authors
- Haojie Ma (ORCID: https://orcid.org/0000-0002-5604-7524)
- Yan Jiang (ORCID: https://orcid.org/0000-0003-3111-4097)
- Yi Yang (ORCID: https://orcid.org/0009-0005-5441-0253)
- Chen-Ying Zhai
- Xuelong Wang
Institutions
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1002/ajoc.202400452
- Citations
- 1
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Sichuan University of Science and Engineering
- Sichuan University