NETs exacerbate placental inflammation and injury through high mobility group protein B1 during preeclampsia
NETs can cause trophoblast inflammation-related functional damage through HMGB1 during the occurrence and development of preeclampsia. HMGB1 produces a marked effect in the PE cascade of oxidative stress involving NETs. Inhibiting HMGB1 to suppress NETs damage is a possible approach for the future treatment of PE.
Authors
- Xiao Liu (ORCID: https://orcid.org/0000-0002-7608-5819)
- Yijia Tian (ORCID: https://orcid.org/0009-0006-1773-749X)
- Xietong Wang (ORCID: https://orcid.org/0000-0002-7207-5971)
- Qinwen Li (ORCID: https://orcid.org/0009-0003-3472-9246)
- Xudong Zhao (ORCID: https://orcid.org/0000-0002-9214-9368)
- Yong‐Jie Tian (ORCID: https://orcid.org/0000-0003-2802-0188)
- Yurong Lu
Institutions
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Shandong Provincial Hospital (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.placenta.2024.12.006
- Citations
- 5
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.91
Funders
- Natural Science Foundation of Shandong Province