Pulmonary consequences of experimentally induced stroke: differences between global and focal cerebral ischemia
Our findings suggest that global cerebral ischemia has no major pulmonary consequences. However, deteriorations in the respiratory tissue mechanics develop after permanent focal ischemia due to pulmonary edema formation, hemoconcentration and cytokine production. This respiratory mechanical defect can compromise lung distension at all PEEP levels, which warrants consideration in optimizing mechanical ventilation.
Authors
- Bence Ballók (ORCID: https://orcid.org/0000-0002-6423-9796)
- Gergely H. Fodor (ORCID: https://orcid.org/0000-0002-4736-4966)
- Eszter Farkas (ORCID: https://orcid.org/0000-0002-8478-9664)
- Judit Danis (ORCID: https://orcid.org/0000-0002-0270-5309)
- Ibolya Tóth
- József Tolnai (ORCID: https://orcid.org/0000-0002-7648-764X)
- Szilvia Kecskés (ORCID: https://orcid.org/0000-0001-7921-4607)
- Ferenc Peták (ORCID: https://orcid.org/0000-0001-6249-9327)
- Petra Somogyi (ORCID: https://orcid.org/0000-0002-8553-142X)
- Zaid Hammad
- Fruzsina Kun-Szabó
- Ramez A. Hussein
Institutions
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fphys.2024.1511638
- Citations
- 2
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Hungarian Scientific Research Fund
- Hungarian Science Foundation
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Horizon 2020 Framework Programme
- National Research, Development and Innovation Office