Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus
These findings support a potential protective causal effect of NK % lymphocyte on LP, partially mediated by Picolinate levels. Thus, interventions targeting Picolinate levels may mitigate LP burden attributed to low NK % lymphocyte counts. This study provides new evidence and insights into the pathogenesis of lichen planus, advancing our understanding of its underlying mechanisms.
Authors
- Jianming Cao (ORCID: https://orcid.org/0000-0002-9968-6721)
- Jia Feng (ORCID: https://orcid.org/0000-0003-0270-7504)
- Guangyong Zhang
- Tao Xu (ORCID: https://orcid.org/0000-0002-5630-0382)
- Ting Du (ORCID: https://orcid.org/0000-0002-9020-3746)
- Baiyu Chen (ORCID: https://orcid.org/0000-0003-3059-6856)
- Jian Li (ORCID: https://orcid.org/0000-0002-4549-0694)
- Xianting Xie
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Qujiang People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1464479
- Citations
- 1
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Southwest Medical University
- Sichuan Province Science and Technology Support Program