Mitochondrial dysfunction signatures in idiopathic primary male infertility: a validated proteomics-based diagnostic approach
This study revealed an association of downregulated expression of PRDX5 and SOD2 in sperm samples of patients with idiopathic primary male infertility. Our results support future mechanistic studies and development of advanced diagnostic methods to better identify men with mitochondria-related male infertility.
Authors
- Sromona Mukherjee (ORCID: https://orcid.org/0000-0003-1958-0220)
- Sarah C. Vij (ORCID: https://orcid.org/0000-0001-8282-2339)
- Raneen Sawaid Kaiyal (ORCID: https://orcid.org/0000-0002-3111-3978)
- Aaron W. Miller (ORCID: https://orcid.org/0000-0001-8342-1449)
- Manesh Kumar Panner Selvam (ORCID: https://orcid.org/0000-0002-9120-2278)
- Scott Lundy
Institutions
- Tulane University (US)
- Cleveland Clinic (US)
Publication Details
- Journal
- Frontiers in Reproductive Health
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/frph.2024.1479568
- Citations
- 4
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 2.15