Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats
We successfully optimized the automated radiosynthesis of <sup>18</sup>F-JNJ64413739. The resulting tracer not only met clinical quality requirements but also demonstrated potential for clinical application in the diagnosis of osteoporosis, as evidenced by higher radioactivity uptake in various brain regions of osteoporotic model rats compared to normal controls.
Authors
- Yan Cui (ORCID: https://orcid.org/0000-0002-2800-6039)
- Yuanfang Jiang
- Hao Xu (ORCID: https://orcid.org/0000-0002-2169-115X)
- Lu Hou (ORCID: https://orcid.org/0009-0005-7559-7256)
- Lu Wang (ORCID: https://orcid.org/0000-0002-3134-2519)
- Yang Qiu
- Yong Lu (ORCID: https://orcid.org/0000-0002-5126-1476)
- Jingjie Shang (ORCID: https://orcid.org/0000-0003-1038-0425)
- Weijian Ye (ORCID: https://orcid.org/0000-0002-0457-3565)
- Bin Guo (ORCID: https://orcid.org/0000-0002-7749-725X)
Institutions
- Jinan University (CN)
- Jiangmen Wuyi Traditional Chinese Medicine Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fphar.2024.1517127
- Citations
- 3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China