Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis
Our findings suggest that Fer-1 inhibits neutrophil infiltration in early sepsis by disrupting the chemokine axis, highlighting its potential as a therapeutic option to manage acute immune overactivation in early stages of sepsis-induced cardiomyopathy.
Authors
- Fu-Li Xiang (ORCID: https://orcid.org/0009-0006-0666-0538)
- Ruoxu Dou (ORCID: https://orcid.org/0000-0002-6572-1664)
- Xiaodong Song (ORCID: https://orcid.org/0000-0002-5932-6916)
- Zhongxing Wang (ORCID: https://orcid.org/0000-0003-0610-5041)
- Changjie Cai (ORCID: https://orcid.org/0000-0003-3120-4658)
- Jie Xu
- Bingqian Lin (ORCID: https://orcid.org/0000-0002-8763-9530)
- Zhilei Huang
- Fang Xiao
- Mingyue Wu
- Jialin Li (ORCID: https://orcid.org/0000-0002-8541-2797)
- Xiangdong Guan
- Huan Ma (ORCID: https://orcid.org/0009-0005-7619-5814)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fcell.2024.1510232
- Citations
- 12
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Natural Science Foundation of China
- Guangdong Science and Technology Department