Impact of steroid therapy on pediatric acute liver failure: prognostic implication and interplay between TNF-α and miR-122
Our data implies that lower miR-122 levels in steroids-treated ALF children are associated with a better outcome. Although miR-122 is not a strong standalone marker, it could be valuable in a biomarker panel. The increased TNF-α levels and decreased miR-122 expression indicate their involvement in the disease's pathophysiology. More studies are needed to validate our results.
Authors
- R. El-Shanawany
- Eman A. El‐maadawy (ORCID: https://orcid.org/0000-0003-2979-2059)
- Roba M. Talaat (ORCID: https://orcid.org/0000-0002-1176-2727)
- Hanaa El-Araby
Institutions
- University of Sadat City (EG)
- Menoufia University (EG)
Publication Details
- Journal
- Molecular and Cellular Pediatrics
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1186/s40348-024-00185-7
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund
- Menofia University