CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds
Our findings suggest that the levels of many brain-derived proteins in CSF may be subjected to dilution effects depending on the size of the brain ventricles in healthy individuals without AD pathology. This phenomenon could potentially contribute to the inter-individual variations observed in CSF proteomic studies.
Authors
- Sára Mravinacová
- Anna Månberg (ORCID: https://orcid.org/0000-0002-0056-1313)
- Olof E. Lindberg (ORCID: https://orcid.org/0000-0001-6352-108X)
- Lars‐Olof Wahlund (ORCID: https://orcid.org/0000-0002-9905-8426)
- Anna Zettergren (ORCID: https://orcid.org/0000-0002-7182-8417)
- Silke Kern (ORCID: https://orcid.org/0000-0001-7617-7214)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Eric Westman (ORCID: https://orcid.org/0000-0002-3115-2977)
- Sofia Bergström (ORCID: https://orcid.org/0000-0003-2910-4754)
- Ingmar Skoog
- Kaj Blennow
Institutions
- University of Wisconsin–Madison (US)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- UK Dementia Research Institute (GB)
- University College London (GB)
- KTH Royal Institute of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1186/s12014-024-09517-1
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- European Commission
- Stiftelsen Handlanden Hjalmar Svenssons
- Kungliga Tekniska Högskolan
- Vetenskapsrådet
- Stiftelsen Psykiatriska Forskningsfonden
- Alzheimerfonden
- Demensfonden
- HORIZON EUROPE Framework Programme