Exploration of key mechanisms underlying the therapeutic effects of AMD3100 on attenuating lipopolysaccharide-induced acute lung injury in mice
Our findings indicate that AMD3100 may exhibit a therapeutic effect on LPS-induced ALI in mice by modulating multiple chemokines to inhibit the Toll-like receptor/nuclear factor-kappa B signaling pathway.
Authors
- Bohan Zhang (ORCID: https://orcid.org/0009-0003-3545-0669)
- Wenwen Dong (ORCID: https://orcid.org/0000-0001-9871-8034)
- Lv Zhou (ORCID: https://orcid.org/0000-0002-9349-6265)
- Yanfei Mao (ORCID: https://orcid.org/0000-0002-0522-5925)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-9692-3026)
- Qihong Yu (ORCID: https://orcid.org/0000-0003-1975-6898)
Institutions
- Second Military Medical University (CN)
- XinHua Hospital (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-12-12
- DOI
- https://doi.org/10.7717/peerj.18698
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- National Natural Science Foundation of China