Diagnostic Accuracy of LiquidArray MTB-XDR VER 1.0 for the Detection of <i>Mycobacterium tuberculosis</i> Complex, Fluoroquinolone, Amikacin, Ethambutol, and Linezolid Susceptibility
LA-XDR met the minimum World Health Organization target product profile for a next-generation, sputum-based, moderate-complexity DST with high fluoroquinolone and ethambutol resistance sensitivity, moderate amikacin resistance sensitivity, and promise for linezolid resistance, for which more data are needed. Improved LA-XDR MTBC detection would reduce missed resistance.
Authors
- Moses Mburu (ORCID: https://orcid.org/0000-0001-7281-583X)
- Robin M. Warren (ORCID: https://orcid.org/0000-0001-5741-7358)
- Yonas Ghebrekristos (ORCID: https://orcid.org/0000-0003-2002-5240)
- Erick Auma (ORCID: https://orcid.org/0000-0001-7076-4944)
- Margaretha de Vos (ORCID: https://orcid.org/0000-0003-3059-2986)
- Brigitta Derendinger
- Morten Rühwald (ORCID: https://orcid.org/0000-0002-1597-441X)
- Elizabeth M. Streicher (ORCID: https://orcid.org/0000-0003-3901-1981)
- Grant Theron (ORCID: https://orcid.org/0000-0002-9216-2415)
- Rouxjeane Venter (ORCID: https://orcid.org/0000-0002-8710-8166)
- Rencia Alberts (ORCID: https://orcid.org/0000-0003-2251-5534)
- Adam Penn‐Nicholson (ORCID: https://orcid.org/0000-0002-1883-0059)
- Samantha Pillay (ORCID: https://orcid.org/0000-0002-4659-4364)
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- FIND (CH)
- National Tuberculosis Institute (IN)
- Stellenbosch University (ZA)
- National Research Foundation (ZA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1093/cid/ciae614
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Bundesministerium für Bildung und Forschung
- National Health Laboratory Service