End-organ Protective Effect of Serelaxin in Patients Hospitalized for Heart Failure: Results of the Biomarker Substudy of Relaxin in Acute Heart Failure-2 (RELAX-AHF-2)
In this substudy, serelaxin decreased plasma concentrations of cardiac, renal and hepatic injury markers. Changes of most of these markers were associated with cardiovascular mortality. In this pre-specified biomarker subgroup, serelaxin did not reduce 180-day cardiovascular mortality but significantly reduced worsening heart failure through day 5.
Authors
- John R. Teerlink (ORCID: https://orcid.org/0000-0001-9527-0852)
- Piotr Ponikowski (ORCID: https://orcid.org/0000-0002-3391-7064)
- Beth A. Davison (ORCID: https://orcid.org/0000-0003-2374-6449)
- G. Michael Felker (ORCID: https://orcid.org/0000-0002-5931-1239)
- Iris E. Beldhuis (ORCID: https://orcid.org/0000-0002-3679-168X)
- Marco Metra (ORCID: https://orcid.org/0000-0001-6691-8568)
- Peter S. Pang (ORCID: https://orcid.org/0000-0003-3444-2811)
- Barry Greenberg (ORCID: https://orcid.org/0000-0002-6605-9385)
- Gad Cotter (ORCID: https://orcid.org/0000-0002-9613-3339)
- Claudio Gimpelewicz (ORCID: https://orcid.org/0000-0001-8700-0641)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Douwe Postmus (ORCID: https://orcid.org/0000-0002-9458-7038)
Institutions
- Novartis (Switzerland) (CH)
- San Francisco VA Medical Center (US)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Duke University (US)
- University of California, San Francisco (US)
- National and Kapodistrian University of Athens (GR)
- Military Hospital (PK)
- University of California System (US)
- University of California San Diego (US)
- Wroclaw Medical University (PL)
- Surgical Specialties (Canada) (CA)
- Momentum Research (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Brescia (IT)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1002/ejhf.3551
- Citations
- 1
- Primary Topic
- Pregnancy-related medical research
- Type
- article
- Field-Weighted Citation Impact
- 0.54