Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance <i>via</i> the CD74/nuclear factor-kappaB pathway in cardiac allograft
Exosomes derived from BMSCs overexpressing miR-540-3p significantly enhance immune tolerance and prolong cardiac allograft survival by modulating the CD74/NF-κB pathway, which regulates activities of DCs and T cells. These findings highlight a promising therapeutic strategy to improve heart transplantation outcomes and potentially reduce the need for prolonged immunosuppression.
Authors
- Fei Mao (ORCID: https://orcid.org/0000-0001-5840-4436)
- Gao-Peng Xiao (ORCID: https://orcid.org/0000-0001-5966-2170)
- Jigang He (ORCID: https://orcid.org/0009-0001-9603-6854)
- Dan Yan (ORCID: https://orcid.org/0000-0003-1424-1625)
- Si Li (ORCID: https://orcid.org/0000-0001-7997-0904)
- Xinxin Wu
Institutions
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2024-12-12
- DOI
- https://doi.org/10.4252/wjsc.v16.i12.1022
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.40