Evaluation of Plasma Neurodegenerative Biomarkers for Diagnosing Minimal Hepatic Encephalopathy and Predicting Overt Hepatic Encephalopathy in Chinese Patients with Hepatic Cirrhosis
The combination of plasma levels of NfL, GFAP, tau, and UCHL1 performs well in diagnosing MHE. Additionally, MELD score, IL-6, and GFAP appear to be significant predictors of OHE development in patients with hepatic cirrhosis.
Authors
- Yunhui Liu (ORCID: https://orcid.org/0000-0003-2773-1447)
- Yuzhao Feng
- Meng Zhang (ORCID: https://orcid.org/0000-0002-5824-9701)
- Tingting Liu (ORCID: https://orcid.org/0000-0003-1420-1287)
- Xiaoyun Zhang (ORCID: https://orcid.org/0000-0002-6239-9569)
- Qin Ning (ORCID: https://orcid.org/0000-0002-2027-9593)
- Tao Chen (ORCID: https://orcid.org/0000-0001-6590-7162)
- Zhongyuan Yang (ORCID: https://orcid.org/0000-0003-4760-1965)
- Xiaoping Luo
- Lanyue Huang
- Yuxin Niu (ORCID: https://orcid.org/0009-0000-1579-9300)
- Qiuyu Cheng
- Wei Liu (ORCID: https://orcid.org/0009-0001-6324-3830)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.14218/jcth.2024.00413
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China