Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells
The acellular peripheral nerve scaffold with complete cell removal and intact matrix may be prepared by combining lyophilization and enzyme digestion. The resulting scaffold exhibited good histocompatibility and low cytotoxicity. In addition, hUC-MSCs have the potential to differentiate into Schwann-like cells with myelinogenic ability following <i>in vitro</i> induction.
Authors
- Chuang Qian (ORCID: https://orcid.org/0000-0003-2375-3614)
- Shuzhen Guo (ORCID: https://orcid.org/0000-0002-8980-9812)
- Hongtao Li (ORCID: https://orcid.org/0000-0001-6532-2092)
- Zhiqiang Zhang (ORCID: https://orcid.org/0000-0002-7779-2937)
- Hao Li (ORCID: https://orcid.org/0000-0003-2832-4851)
- Xiongsheng Chen (ORCID: https://orcid.org/0000-0002-7867-7295)
- Zheng Xu
Institutions
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2024-12-12
- DOI
- https://doi.org/10.4252/wjsc.v16.i12.1047
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.27