Explore the influence of circadian clock on acne

Acne is a disease which have some stimulate compound secret on our face surface or other parts of our body. Acne is a chronic inflammatory skin disease that affects the sebaceous gland units of the skin, characterized by open and closed comedones, papules, pustules, and cysts. It impacts nearly 50 million individuals in the United States. Its pathogenesis involves follicular hyper-keratinization, inflammation, in part generated by Cutibacterium acnes (formerly Proprionibacterium acnes) and hormonal alterations acne. The circadian clock was shown to be strongly correlated. As a natural rhythm in the body, the circadian clock can regulate and control a variety of physiological activities and behaviors. Its disturbance not only affects the quality of sleep, but also further affects endocrine, skin metabolism and other aspects, thus becoming an important factor in the generation of acne. The purpose of this paper is to summarize the influence of the circadian clock on acne generation, and to explain how the disturbance of the circadian clock leads to the occurrence and aggravation of acne through comprehensive analysis of existing research results.