Advances in Drug Treatment of Refractory Epilepsy

Refractory epilepsy is a nervous system disease that does not respond well to conventional anti-epileptic drugs, and has always been a difficult problem to be solved in the medical field. The purpose of this paper is to comprehensively review and analyze the current progress of drug therapy for refractory epilepsy, in order to provide reference for future clinical practice and research. In this paper, the definition, classification, pathogenesis and mechanism of refractory epilepsy were summarized. Subsequently, the application and limitations of traditional antiepileptic drugs, as well as the development and clinical application of new antiepileptic drugs, such as CBD and P2X7R, were discussed in detail. This paper looks forward to the future research direction and challenges, focusing on the trends and challenges of new drug development, as well as the application prospects of precision medicine in the treatment of refractory epilepsy. Finally, it is pointed out that the future treatment of refractory epilepsy still needs to face the technical maturity of advanced technology in practical application, and the development of new drugs and new treatments requires a lot of money and time investment, and clinical trials may fail.