The Role of Circadian Rhythm Disruption in Prostate Cancer Development: Epidemiological, Molecular, and Therapeutic Perspectives

Circadian rhythm disruption has been increasingly recognized as a critical factor in the development and development of prostate cancer. Through a comprehensive examination of epidemiological evidence, molecular pathways, and experimental studies, circadian misalignment is shown to influence key biological processes that regulate hormone production, DNA repair, and immune function, all essential to maintaining cellular homeostasis. Disruptions in circadian rhythms can lead to altered gene expression, impacting pathways associated with tumour development. Epidemiological data reveal an elevated risk of prostate cancer in individuals with irregular circadian patterns, such as shift workers, further reinforcing the link between circadian dysregulation and cancer risk. Molecular studies have identified potential therapeutic targets within circadian- regulated pathways, offering new opportunities for intervention. Therapeutic approaches aimed at restoring circadian alignment may not only prevent prostate cancer but also improve treatment outcomes by enhancing the effectiveness of current therapies. Understanding the character of circadian rhythms in prostate cancer opens new avenues for prevention and treatment strategies that could ultimately improve patient prognosis. This paper delves into the strong link between circadian rhythm disruption and prostate cancer. Based on the comprehensive analysis of the basic concept of circadian rhythm, the characteristics of prostate cancer, and the epidemiological evidence, molecular mechanism, experimental studies and potential therapeutic targets associated with the two, it is concluded that circadian rhythm disorder plays a crucial role in the occurrence and development of prostate cancer, which provides a new perspective and direction for the prevention and treatment of prostate cancer.