Biochemical and cellular mechanisms of immunogenic cell death

Immunogenic cell death (ICD) is a mode of programmed cell death that leads to the activation of anticancer immune response and determines the long-term success of anticancer therapies. Here, we provide a review of the known molecular and cellular mechanisms of ICD. Usually, solid tumor experimental models have been used in ICD studies. However, ascites tumor models may possess some advantages over them. The results of our investigation on the approbation of murine Nemeth-Kellner lymphoma as an experimental ascites tumor model for ICD studies are presented. Keywords: ascites tumor model, biochemical mechanisms, doxorubicin, immunogenic cell death, murine Nemeth-Kellner lymphoma, oxaliplatin