Analysis of the principles and development history of CAR T cell immunotherapy

With the increasing causes of cancer and the improvement of cancer diagnosis rates, the global burden of cancer is becoming increasingly severe. But at the same time, researchers are also gaining a better understanding of cancer and accumulating more and more experience in fighting cancer, which has improved the survival rate of cancer. The treatment method that modifies T cells with CAR genes to have anti-cancer effects has been named CAR T cell immunotherapy by researchers. This immunotherapy significant achievements have been made in the field of hematology treatment. tumors, and the related drug Kyrmiah was approved for market in 2017. This article briefly explains the basic principles of CAR T cell immunotherapy by integrating textual materials, and reviews and summarizes the development history and main achievements of this immunotherapy. By summarizing and organizing, exploratory learners quickly and directly understand the basic information of CAR T cell immunotherapy. Hope to help capable scholars accumulate relevant knowledge, discover and solve new problems discovered in the practical application of this therapy in the future, expand its application scope, reduce treatment costs, and enable more cancer patients in need of this technology to receive assistance.