Sex Differences in Cardiovascular-Kidney-Metabolic Syndrome: 30-Year US Trends and Mortality Risks—Brief Report
Women, compared with men, exhibited a lower prevalence of CKM stage 3 but experienced excess mortality risk across the spectrum of multisystem CKM dysfunction. These findings underscore the importance of identifying mechanisms underlying joint cardiovascular, kidney, and metabolic system pathophysiology to close a potentially widening sex disparities gap in multiorgan disease risk.
Authors
- Bin Sheng (ORCID: https://orcid.org/0000-0001-8678-2784)
- Charumathi Sabanayagam (ORCID: https://orcid.org/0000-0002-4042-4719)
- Huating Li (ORCID: https://orcid.org/0000-0003-0526-5545)
- Susan C. Cheng (ORCID: https://orcid.org/0000-0002-4977-036X)
- Hongwei Ji
- Tyler Hyungtaek Rim (ORCID: https://orcid.org/0000-0001-6465-2620)
- Tien Yin Wong (ORCID: https://orcid.org/0000-0002-8448-1264)
- Yih Chung Tham (ORCID: https://orcid.org/0000-0002-6752-797X)
- Kunihiro Matsushita (ORCID: https://orcid.org/0000-0002-7179-718X)
- Ching‐Yu Cheng
Institutions
- Johns Hopkins University (US)
- Shanghai Jiao Tong University (CN)
- Singapore National Eye Center (SG)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Cedars-Sinai Smidt Heart Institute (US)
- Shanghai Sixth People's Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1161/atvbaha.124.321629
- Citations
- 48
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 19.30
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China