<i>Porphyromonas gingivalis</i> ‐Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis
This study novelly discovered that both P. gingivalis-LPS-stimulated HGFs and IGFs in periodontitis acquired trained immunity. Following P. gingivalis-LPS stimulation, HGFs underwent metabolic and epigenetic changes via the PI3K/AKT pathway, with these epigenetic changes also observed in IGFs. This finding suggests that trained immunity in GFs may be a key mechanism underlying the recurrence and persistence of periodontitis.
Authors
- Pishan Yang (ORCID: https://orcid.org/0000-0002-7326-9452)
- J. Liu
- Haoyang Tian (ORCID: https://orcid.org/0000-0002-8691-1045)
- Suli Wang (ORCID: https://orcid.org/0009-0008-9932-4326)
- Ji-Min Ju (ORCID: https://orcid.org/0000-0002-0000-7232)
- Fujiao Nie
- Jingjing Zhao (ORCID: https://orcid.org/0009-0009-8831-0436)
- Hongmei Guo (ORCID: https://orcid.org/0000-0003-4082-7363)
- Qianqian Yin (ORCID: https://orcid.org/0000-0002-3144-0442)
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1111/jre.13372
- Citations
- 10
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- National Natural Science Foundation of China
- Key Technology Research and Development Program of Shandong