DCBLD1 Modulates Angiogenesis by Regulation of the VEGFR-2 Endocytosis in Endothelial Cells
These findings demonstrated the essential role of endothelial DCBLD1 in regulating VEGF signaling and provided evidence that DCBLD1 promotes VEGF-induced angiogenesis by limiting the dephosphorylation, ubiquitination, and lysosome degradation after VEGFR-2 endocytosis. We proposed that endothelial DCBLD1 is a potential therapeutic target for ischemic cardiovascular diseases by the modulation of angiogenesis through regulation of the VEGFR-2 endocytosis.
Authors
- Demin Liu (ORCID: https://orcid.org/0000-0002-8784-1026)
- Yanhong Zong
- Lei Nie (ORCID: https://orcid.org/0000-0001-7473-5040)
- Yuehua Ma
- Runtao Wang
- Wenjun Zhang
- Lingling Guo (ORCID: https://orcid.org/0000-0003-2011-4171)
- Mei Han (ORCID: https://orcid.org/0000-0002-5338-4875)
- Weiwei Yang (ORCID: https://orcid.org/0000-0001-9465-7887)
- Chao Yu
- Honglin Niu (ORCID: https://orcid.org/0000-0003-0710-5959)
- Yunli Pei (ORCID: https://orcid.org/0009-0004-4853-2679)
- Chenyang Li (ORCID: https://orcid.org/0000-0001-6031-6435)
- Xiaoning Liu (ORCID: https://orcid.org/0000-0001-9796-9309)
- Hui‐Fang Wang (ORCID: https://orcid.org/0000-0001-5867-4401)
- Lijing Li (ORCID: https://orcid.org/0000-0001-5195-6270)
- Feng Qi (ORCID: https://orcid.org/0009-0008-1153-9892)
- Yan-Ling Lin (ORCID: https://orcid.org/0000-0002-0382-7148)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1161/atvbaha.123.320443
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47