Semaglutide Improves Myocardial Perfusion and Performance in a Large Animal Model of Coronary Artery Disease
This study reveals the capacity of oral SEM to augment cardiac function in the chronically ischemic heart in a highly translational large animal model, likely through AMPK-mediated improvement in endothelial function and perfusion to the ischemic myocardium.
Authors
- Frank W. Sellke (ORCID: https://orcid.org/0000-0002-8886-801X)
- Mark Broadwin (ORCID: https://orcid.org/0000-0002-0393-9983)
- Dwight D. Harris (ORCID: https://orcid.org/0000-0001-8289-2740)
- M. Ruhul Abid (ORCID: https://orcid.org/0000-0003-2981-2638)
- Christopher Stone (ORCID: https://orcid.org/0000-0001-6457-2663)
- Keertana Yalamanchili
- Meghamsh Kanuparthy (ORCID: https://orcid.org/0009-0005-7581-0555)
- Jad Hamze (ORCID: https://orcid.org/0009-0000-2758-8746)
- Ju-Woo Nho (ORCID: https://orcid.org/0009-0006-1260-070X)
Institutions
- Brown University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1161/atvbaha.124.321850
- Citations
- 14
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- Brown University
- Rhode Island Foundation
- National Institutes of Health