Extracellular Vesicles From Preeclampsia Disrupt the Blood-Brain Barrier by Reducing CLDN5
sEVs-PE disrupts the blood-brain barrier, an effect replicated with sEVs-Hyp, and involves reduced CLDN5 and elevated VEGF contained within these vesicles. However, our results do not support the participation of KDR activation in the downregulation of CLDN5 observed with sEVs-Hyp. These findings will improve our understanding of the pathophysiology of cerebrovascular alterations in women with preeclampsia.
Authors
- D. Caamaño (ORCID: https://orcid.org/0000-0002-2772-8793)
- Belén Ibáñez (ORCID: https://orcid.org/0009-0006-5449-460X)
- Hiten D. Mistry (ORCID: https://orcid.org/0000-0003-2564-7348)
- Hermes Sandoval
- Lidice Mendez (ORCID: https://orcid.org/0009-0002-1109-6936)
- Francisco Nualart (ORCID: https://orcid.org/0000-0002-7762-1417)
- Moisés Contreras
- Carlos Escudero (ORCID: https://orcid.org/0000-0001-7688-4621)
- Fidel Ovídio Castro (ORCID: https://orcid.org/0000-0001-8828-1449)
- Manu Vatish (ORCID: https://orcid.org/0000-0002-6012-2574)
- Felipe Troncoso (ORCID: https://orcid.org/0009-0007-9567-1227)
- Lesia O. Kurlak (ORCID: https://orcid.org/0000-0001-7938-6994)
- Estefanny Escudero-Guevara (ORCID: https://orcid.org/0009-0009-5522-6705)
- Jesenia Acurio
Institutions
- University of Talca (CL)
- University of Nottingham (GB)
- University of Concepción (CL)
- King's College London (GB)
- John Radcliffe Hospital (GB)
- Universidad Adventista de Chile (CL)
- University of Bío-Bío (CL)
- Institute of Cell Biology and Neurobiology (IT)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1161/atvbaha.124.321077
- Citations
- 12
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 6.99