Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies
Anti-CD47 mAb can quench DEMs while exposing pro-phagocytic signals, promoting tumor cell phagocytosis. ALK inhibitors induced immunogenic cell damage by upregulating CALR in both sensitive and off-target resistant tumors. Continuous TKIs exposure in off-target resistant settings also resulted in the upregulation of CD47 over time. Combining TKIs with a CD47 blockade may offer therapeutic benefits in ALK+ cancers, especially in overcoming off-target resistance where TKIs alone are less effective.
Authors
- Chiara Scollo
- Ilaria Crespiatico (ORCID: https://orcid.org/0000-0002-4269-3023)
- Elisa Bossi (ORCID: https://orcid.org/0000-0003-1303-9580)
- Daniele Ramazzotti (ORCID: https://orcid.org/0000-0002-6087-2666)
- Andrea Aroldi (ORCID: https://orcid.org/0000-0002-3428-5353)
- Carolina Steidl (ORCID: https://orcid.org/0000-0002-9836-5299)
- Carlo Gambacorti‐Passerini (ORCID: https://orcid.org/0000-0001-6058-515X)
- Federica Cocito (ORCID: https://orcid.org/0000-0002-8700-8229)
- Rocco Piazza (ORCID: https://orcid.org/0000-0003-4198-9620)
- Luca Mologni (ORCID: https://orcid.org/0000-0002-6365-5149)
- Mario Mauri (ORCID: https://orcid.org/0000-0002-5876-6215)
- Federica Malighetti (ORCID: https://orcid.org/0009-0009-2492-8974)
- Valentina Crippa (ORCID: https://orcid.org/0000-0003-2324-7164)
- Matteo Villa (ORCID: https://orcid.org/0000-0002-6534-642X)
- Ivan Civettini (ORCID: https://orcid.org/0000-0002-7707-584X)
- Simone Piane
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Vita-Salute San Raffaele University (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3390/biomedicines12122819
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Dipartimenti di Eccellenza
- European Commission
- Associazione Italiana per la Ricerca sul Cancro